Dresser M, Desai D, Gidwani S, Seftel A, Modi N. Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors Int J Impot Res. Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction Int J Impot Res. Evidence-based multiple action points for public awareness, screening, and treatment: An extension of Asian-Pacific recommendations Asia Pac J Clin Nutr. Obesity and erectile dysfunction: From bench to clinical implication World J Mens Health. Nehra A.
About the Company
Al-Saeed AH, Constantino MI, Molyneaux L, D’Souza M, Limacher-Gisler F, Luo C, et al An inverse relationship between age of type 2 diabetes onset and complication risk and mortality: The impact of youth-onset type 2 diabetes Diabetes Care. Colson M, Cuzin B, Faix A, Grellet L, Huyghes E. Current epidemiology of erectile dysfunction, an update Sexologies. Diabetes-induced erectile dysfunction: Epidemiology, pathophysiology and management J Diabetes Complications. Hicks CW, Wang D, Windham BG, Selvin E.
Effect of co-morbidities on treatment outcome
Association of peripheral neuropathy with erectile dysfunction in US men Am J Med. Redrow GP, Thompson CM, Wang R. Treatment strategies for diabetic patients suffering from erectile dysfunction: An update Expert Opin Pharmacother. Hatzimouratidis K, Hatzichristou D. How to treat erectile dysfunction in men with diabetes: From pathophysiology to treatment Curr Diab Rep.
27 May – 1 June 2026
2014;14:545. Phosphodiesterase-5 (PDE5) inhibitors in the management of erectile dysfunction P T. 2013;38:407–19 Tadalafil in the treatment of erectile dysfunction Ther Clin Risk Manag. Recent advances in the understanding and management of erectile dysfunction F1000Res. Treatment options for erectile dysfunction Endocrinol Metab Clin buy cheap dapoxetine North Am. Erectile dysfunction and cardiovascular disease: Efficacy and safety of phosphodiesterase type 5 inhibitors in men with both conditions Mayo Clin Proc. The association between erectile dysfunction and cardiovascular risk in men with Type 2 diabetes in primary care: It is a matter of age J Diabetes Complications. Seftel AD, Sun P, Swindle R. The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction J Urol. Nakanishi S, Yamane K, Kamei N, Okubo M, Kohno N. Erectile dysfunction is strongly linked with decreased libido in diabetic men Aging Male. Fedele D, Coscelli C, Santeusanio F, Bortolotti A, Chatenoud L, Colli E, et al Erectile dysfunction in diabetic subjects in Italy. Tadalafil and Dapoxetine are found to be the two active ingredients that are responsible for giving men a break from sexual weakness. Yes, they are proven to be the best oral medicine for overcoming erectile dysfunction. But alongside that, premature ejaculation is also controlled by its consumption. As Tadalafil is found to belong to the class of drugs PDE-5 inhibitors, which mainly help to improve the flow of blood in the penis. Whereas the role of Dapoxetine is a selective serotonin reuptake inhibitor that helps to delay the ejaculation process. No dapoxetine sex doubt, the combination of the medicines allows men to overcome and balance their sexual lives quickly and without getting stressed or delayed. The use of Tadalafil and Dapoxetine is found to be helpful for men only, and this makes them withstand (during intercourse) and obtain complete pleasure. Tadalafil is a medicine that helps to fight and control erectile dysfunction. Men, at the time of obtaining pleasure, do not have to think twice. But one dose before making love will help overcome weakness. Whereas the role of Dapoxetine helps to control ejaculation. This means it increases control over ejaculation so that men can withstand longer during sex. In short, this improves the duration of overall intercourse. Consulting your doctor before taking Dapoxetine and Tadalafil is a necessity. This is mainly required for those with severe heart issues or other conditions. If you are taking other medicines for other health treatments, you must not wait but discuss them with the doctor beforehand. Discuss your case if you encounter any allergies upon consuming both medicines.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Priligy Generic Dapoxetine | 60mg | 60 + 8 Pills | 183.06€ 174.34€ | |
| Viagra Generic | 25mg | 10 Pills | 25.19€ 23.99€ | |
| Priligy Generic Dapoxetine | 60mg | 30 + 6 Pills | 106.65€ 101.57€ | |
| Cialis Professional | 40mg | 60 + 2 Pills | 262.32€ 249.83€ | |
| Cialis Professional | 20mg | 360 + 6 Pills | 807.03€ 768.60€ | |
| Cialis Original | 20mg | 22 + 2 Pills | 129.20€ 123.05€ | |
| Viagra Original | 100mg | 48 + 4 Pills | 207.15€ 197.29€ | |
| Priligy Generic Dapoxetine | 60mg | 120 + 10 Pills | 341.26€ 325.01€ | |
| Levitra Soft Tabs | 20mg | 360 + 20 Pills | 682.21€ 649.72€ | |
| Priligy Generic Dapoxetine | 60mg | 10 Pills | 47.63€ 45.36€ | |
| Cialis Soft Tabs | 20mg | 120 + 6 Pills | 248.64€ 236.80€ | |
| Priligy Generic Dapoxetine | 60mg | 20 + 4 Pills | 77.31€ 73.63€ | |
| Priligy Generic Dapoxetine | 60mg | 90 + 10 Pills | 265.64€ 252.99€ | |
| Levitra Generic | 40mg | 60 + 4 Pills | 162.37€ 154.64€ | |
| Cialis Generic | 20mg | 20 Pills | 54.72€ 52.11€ | |
| Priligy Generic Dapoxetine | 60mg | 180 + 10 Pills | 494.76€ 471.20€ |
Both Tadalafil and Dapoxetine help men to overcome difficulty smoothly.
Regulatory history
There was no indication of superiority of either. Both Tadalafil and Tadalafil + Dapoxetine improved most of the IIEF parameters. Thus, there appears to be no masking effect on the efficacy of Tadalafil when it is used in combination with Dapoxetine. Moreover, the Tadalafil + Dapoxetine combination improved all the IIEF parameters for subjects with high BMI except for SD. In subjects with co-morbidities, the use of either Tadalafil or Tadalafil + Dapoxetine drug combination was shown to significantly enhance all the IIEF scores, suggesting a strong correlation between comorbidities and ED.
Q7: What should I do if I experience a prolonged erection (lasting more than four hours)?
The findings of the present study highlight the high prevalence of ED in men suffering from T2DM. An imbalanced physiological profile, such as higher BMI, higher HbA1c, lower testosterone, disturbed lipid profile, and a lower VitB12 level is reported to be major contributors to ED. In addition to this, the presence of comorbidities such as hypertension, dyslipidemia, and coronary artery disease further elevates the odds of developing ED. The treatment of individuals with T2DM with Tadalafil and Tadalafil + Dapoxetine drug combination shows promising results in improving ED, as analyzed using the IIEF questionnaires. However, no clear advantage of combination of the two drugs was observed.
Chemical Names
This study lays the foundation of long-term prospective clinical studies to validate the efficacy of using Tadalafil + Dapoxetine drug combination in managing ED in individuals with T2DM. The findings of this study also outline the pressing need of careful examination of sexual dysfunction in healthcare clinics for diabetic individuals. Increased awareness through routine screening for ED can contribute to the timely diagnosis and effective treatment of ED especially in elderly population. The authors of this study do not have any conflicts of interest with publication of the manuscript or an institution or product that is mentioned in the manuscript and/or is important to the outcome of the study presented. Dr. As mentioned above, Tadalafil belongs to the PDE5, which in turn promotes the dilation of the blood vessels.
Conflict of interest statement
The effectiveness of psychological interventions for the treatment of erectile dysfunction: Systematic review and meta-analysis, including comparisons to sildenafil treatment, intracavernosal injection, and vacuum devices J Sex Med. Current diagnosis and management of erectile dysfunction Med J Aust. Etiology of erectile dysfunction and duration of symptoms in patients undergoing penile prosthesis: A systematic review Sex Med Rev. Dapoxetine: A new option in the medical management of premature ejaculation Ther Adv Urol. Efficacy and safety of dapoxetine/sildenafil combination tablets in the treatment of men with premature ejaculation and concomitant erectile dysfunction-DAP-SPEED study Int J Impot Res. Once your blood vessels get smoother, there is a sufficient flow of blood toward the penis. This, in turn, helps to obtain the desired erections for maintaining sexual intercourse. In other cases, Sildenafil Citrate and Vardenafil works by inhibiting the reuptake of serotonin, a neurotransmitter that affects overall mood and ejaculation timing. This, in turn, delays ejaculation and prolongs intercourse. You must swallow the tablet with water; this is the right measure to control ED and PE.
- Tadalafil can interact with certain medications like alpha-blockers.
- Dapoxetine may cause dizziness affecting coordination and alertness.
- Patients with heart conditions should discuss risks before use.
- Combining these drugs may require dose adjustments to reduce side effects.
- Tadalafil should not be taken with heavy meals which delay absorption.
- Dapoxetine's safety profile is established for short-term use.
The medicine can be taken with or without food, which is entirely up to your mood. Along with the consumption, you need to ensure that you are limiting poor habits like those of consuming alcohol and smoking. It is advisable to take Tadalafil and Dapoxetine only with water and not using crushing or chewing. You need to consider all of the instructions that come with the medicine to take advantage of all the benefits. You need to avoid consuming Tadalafil, Dapoxetine, and medications containing nitrates. Do not consume other antibiotics, alpha-blockers, or certain antifungal or antiviral medications. If you are consuming alcohol, then do consider consulting your case with a doctor.
Preparing for your appointment
Amol Chaudhari is also a part of the scientific department at Neovation Consultancy Services Pte. Dr. Vipul Chavda conceived the idea and design for the study and overlooked the entire study until completion. Dr. Santosh Jha made major contributions in drafting the manuscript and statistical analysis.
Depression and anxiety
Dr. Tejal Gandhi and Anjali Patel conducted manuscript editing and reviewing. Literature search and clinical data collection was done by Hiren Raninga. Dr. Amol Chaudhari and Dr.
Special dosage considerations
Dhruvi Hasnani performed statistical analysis on the collected data, wrote and reviewed the manuscript. Vibhuti Jain Rana, Nishtha Singh, and Pusala Lakshmi Prasanna from Neovation Consultancy Services Pte. Ltd., Singapore, for assisting with statistical analysis and manuscript revision. Sexual dysfunction in men with type II diabetes Caspian J Intern Med. Definition, classification and diagnosis of diabetes mellitus Exp Clin Endocrinol Diabetes. Tadalafil helps enhance the flow of blood to the penis, which in turn helps obtain erections for more extended periods during sex. Whereas Dapoxetine helps increase the level of serotonin in the brain and helps control ejaculation. This, in turn, helps extend the time for sexual activity or obtaining pleasure. If you have a history of heart conditions, liver, kidney, and other significant issues, do not consume Tadalafil and Dapoxetine.
| Study Type | Sample Size | Key Findings | Duration of Study |
|---|---|---|---|
| Randomized Trial | 200 patients | Significant improvement in erectile function and ejaculation latency | 12 weeks |
| Meta-analysis | 15 studies | Combination therapy superior to monotherapy in ED and PE | N/A |
| Patient Surveys | 300 patients | High satisfaction rates, minimal side effects | 6 months |
If you develop allergies quickly or after consuming Tadalafil and dapoxetine, avoid taking them. You need to avoid combining nitrates with Tadalafil and dapoxetine.
- Tadalafil is a medication used to treat erectile dysfunction and BPH.
- Dapoxetine is prescribed for premature ejaculation in men.
- Tadalafil has a long duration, up to 36 hours of efficacy.
- Dapoxetine acts as a selective serotonin reuptake inhibitor (SSRI).
- Both drugs may have side effects like headaches and dizziness.
- Combining these medications should be done under medical supervision.
Taking too much of either Tadalafil or Dapoxetine can lead you to experience severe or mild side effects.
- Tadalafil is marketed under brand names like Cialis.
- Dapoxetine is available in various countries, often as brand Priligy.
- Tadalafil can also help in the treatment of pulmonary hypertension.
- Dapoxetine reduces the urgency and frequency of premature ejaculation.
- Missed doses of tadalafil should be taken as soon as remembered.
- Do not exceed the recommended dose to avoid severe side effects.
Hence, you need to consume only the required dose and not more.