[22] Human ejaculation is regulated by various areas in the central nervous system (CNS). These signals are passed on to the brain stem, which then is influenced by a number of nuclei in the priligy 90 mg brain such as medial preoptic and paraventricular nuclei. [24] Clement's study performed on anaesthetized male rats showed that acute administration of dapoxetine inhibits ejaculatory expulsion reflex at supraspinal level by modulating activity of lateral paragigantocellular nucleus (LPGi) neurons. These effects cause an increase in pudendal motoneuron reflex discharge (PMRD) latency, though whether dapoxetine acts directly on LPGi or on the descending pathway in which LPGi located is unclear. Dapoxetine is a white, powdery, water-insoluble substance. Taken one to three hours before sexual activity, it is rapidly absorbed in the body.

Contra Indications

These pharmacokinetics are more favorable in that they might minimize drug accumulation in the body, habituation, and side effects. Dapoxetine was initially considered unsuccessful in its intended use as an antidepressant; however, it has since been investigated as a possible aid to an approach to depression treatment focused on stress reduction, based on an animal model of depression. Dapoxetine should not be used in men with moderate to severe hepatic impairment and in those receiving CYP3A4 inhibitors such as ketoconazole, ritonavir, and telithromycin. Dapoxetine also cannot be used in patients with heart failure, permanent pacemaker, or other significant ischemic heart disease. Caution is advised in men receiving thioridazine, monoamine oxidase inhibitors, SSRIs, serotonin-norepinephrine reuptake inhibitors, or tricyclic antidepressants.

Neurocognitive safety

Taken as needed, dapoxetine has very mild adverse effects of decreased libido (<1%) and erectile dysfunction (<4%). No case of drug overdose has been reported during clinical trials. Many men who have PE also suffer from erectile dysfunction (ED). Treatment for these patients should consider the drug–drug interaction between dapoxetine and PDE5 inhibitors such as tadalafil (Cialis) or sildenafil (Viagra). In Dresser study (2006), plasma concentration of 24 subjects was obtained. Its maximum plasma concentration (Cmax) is reached one to two hours after oral administration. The Cmax and AUC (area under the plasma vs. time curve) is dose dependent. The Cmax and Tm (time needed to obtain the maximum plasma concentration) after single doses of dapoxetine 30 mg and 60 mg are 297 and 498 ng/ml at 1.01 and 1.27 hours, respectively.

Product	Dosage	Quantity + Bonus	Price
Levitra Soft Tabs	20mg	20 Pills	74.68€ 71.12€
Priligy Generic Dapoxetine	60mg	90 + 10 Pills	265.64€ 252.99€
Priligy Generic Dapoxetine	60mg	60 + 8 Pills	183.06€ 174.34€
Priligy Generic Dapoxetine	60mg	20 + 4 Pills	77.31€ 73.63€
Cialis Soft Tabs	20mg	270 + 10 Pills	471.40€ 448.95€
Cialis Black	80mg	180 + 10 Pills	356.64€ 339.66€
Priligy Generic Dapoxetine	60mg	180 + 10 Pills	494.76€ 471.20€
Priligy Generic Dapoxetine	60mg	10 Pills	47.63€ 45.36€
Cialis Generic	5mg	360 + 10 Pills	268.08€ 255.31€
Cialis Generic	40mg	60 + 6 Pills	130.98€ 124.74€
Priligy Generic Dapoxetine	60mg	30 + 6 Pills	106.65€ 101.57€
Viagra Super Active	100mg	60 + 8 Pills	116.84€ 111.28€
Kamagra Polo	100 mg	12 Pills	60.21€ 57.34€
Levitra Soft Tabs	20mg	30 + 2 Pills	99.17€ 94.45€
Priligy Generic Dapoxetine	60mg	120 + 10 Pills	341.26€ 325.01€
Levitra Soft Tabs	20mg	60 + 4 Pills	178.40€ 169.90€
Kamagra Polo	100 mg	120 + 6 Pills	327.15€ 311.57€

A high-fat meal does reduce the Cmax slightly, but it is insignificant.

Important information about Priligy

See the information below and, if you need to, ask your doctor or pharmacist if you have any further questions about side effects. Tell your doctor or pharmacist if you notice anything else that may be making you feel unwell. Other side effects not listed here may occur in some people. After you have received medical advice for any side effects you experience, you can report side effects to the Therapeutic Goods Administration online at By reporting side effects, you can help provide more information on the safety of this medicine. Always make sure you speak to your doctor or pharmacist before you decide to stop taking any of your medicines.

What PRILIGY looks like

This medicine is only available with a doctor's prescription. This medicine does not contain sucrose, gluten, tartrazine or any other azo dyes. Do not take this medicine if you are allergic to any of these ingredients. PRILIGY 30 mg film-coated tablets are light grey, round and marked "30" inside a triangle on one side (AUST R 147946). PRILIGY is supplied in blister packs containing 3 or 6 tablets.

Drinking alcohol

This leaflet was prepared in March 2024. Dapoxetine, sold under the brand name Priligy among others, is a selective serotonin reuptake inhibitor (SSRI) used for the treatment of premature ejaculation (PE) in men ages 18 to 64 years old. [3][4][5] Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin's action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay. [6] As a member of the SSRI family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. It can be taken with or without food. Dapoxetine is absorbed and distributed rapidly in the body.

Advice	Rationale	Additional Notes
Avoid alcohol	Enhances side effects, impairs judgment	For optimal safety
Report adverse effects	Ensures proper management	Contact healthcare provider swiftly
Do not double dose	Risk of overdose and side effects	Follow prescribed instructions
Use only as directed	Prevent misuse or dependence	Not for daily use or recreational use

The mean steady-state volume is 162 L.

Priligy is the brand name for dapoxetine.
It is used to treat premature ejaculation.
Dapoxetine is a selective serotonin reuptake inhibitor.
The medication is taken 1 to 3 hours before sex.
Common side effects include nausea and dizziness.
Priligy is approved in many countries for PE.
Do not take with alcohol or CYP inhibiting meds.
Consult a doctor before starting Priligy.
It is available in 30 mg and 60 mg doses.

Its initial half-life is 1.31 hours (30 mg dose) and 1.42 hours (60 mg dose), and its terminal half life is 18.7 hours (30 mg dose) and 21.9 hours (60 mg dose). Dapoxetine is metabolized extensively in the liver and kidney by multiple enzymes such as CYP2D6, CYP3A4, and flavin monooxygenase 1.

1. Why am I taking PRILIGY?

Half of the sample pool were treated with dapoxetine 60 mg plus tadalafil 20 mg; the other half were treated with dapoxetine 60 mg plus sildenafil 100 mg. These plasma samples were then analyzed using liquid chromatography-tandem mass spectrometry. The results showed that dapoxetine does not alter the pharmacokinetics of tadalafil or sildenafil. Alcohol does not affect the pharmacokinetics of dapoxetine when taking concurrently. The mechanism through which dapoxetine affects premature ejaculation is still unclear, but dapoxetine is presumed to work by inhibiting serotonin transporter (SERT) and subsequently increasing serotonin's action at pre- and postsynaptic receptors. The major product at the end of the metabolic pathway is circulating dapoxetine N-oxide, which is a weak SSRI and contributes no clinical effect. The metabolites of dapoxetine are eliminated rapidly in the urine with a terminal half-life of 18.7 and 21.9 hours for a single dose of 30 mg and 60 mg, respectively. The cardiovascular safety profile of dapoxetine has been studied extensively during the drug development. Phase I trials showed that dapoxetine had neither clinically significant electrocardiographic effects nor delayed repolarization effects, with dosing up to four-fold greater than the maximum recommended dosage, which is 60 mg. Phase III studies in men with PE showed a safety and well tolerated profile of dapoxetine with dosing of 30 and 60 mg.

Priligy helps improve control over ejaculation.
It is generally well-tolerated with few side effects.
Patients should avoid driving after use.
Overdose can cause serious health issues.
Use only as directed by your healthcare provider.
Priligy is not recommended for women.
It's effective for rapid ejaculation lasting less than 1 minute.
The medication can be part of a broader treatment plan.
Regular medical check-ups are advised during use.

No cardiovascular adverse had been found. Studies of SSRIs in patients with major psychiatric disorders prove that SSRIs are potentially associated with certain neurocognitive adverse effects such as anxiety, akathisia, hypomania, changes in mood, or suicidal thought. [30][31] No study on the effects of SSRIs in men with PE has been done. McMahon's study in 2012 showed that dapoxetine has no effect on mood and is not associated with anxiety or suicidality.

Quick Tips

Its fast-acting property makes it suitable for the treatment of PE, but not as an antidepressant. Originally created by Eli Lilly pharmaceutical company, dapoxetine was sold to Johnson & Johnson in 2003 and submitted as a New Drug Application to the US Food and Drug Administration (FDA) for the treatment of PE in 2004. [8] Dapoxetine is sold in several European and Asian countries, and in Mexico. In the US, dapoxetine has been in phase III development. In May 2012, US-based Furiex Pharmaceuticals reached an agreement with ALZA Corp and Janssen Pharmaceuticals to market dapoxetine in the United States, Japan, and Canada, while selling the rights to market the drug in Europe, most of Asia, Africa, Latin America, and the Middle East to Menarini.

Less serious side effects

Randomized, double-blind, placebo-controlled trials have confirmed the efficacy of dapoxetine for the treatment of PE. [10] Different dosages have different impacts on different types of PE. Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 mg in men with lifelong PE, but no difference is seen in men with acquired PE. [11] Dapoxetine, given 1–3 hours before sexual episode, prolongs IELT and increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE. Since PE is associated with personal distress and interrelationship difficulty, dapoxetine provides help for men with PE to overcome this condition.

Pregnancy and breastfeeding

With no drug approved specifically for treatment for PE in the US and some other countries, other SSRIs order priligy low cost such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used off-label to treat PE. Waldinger's meta-analysis shows that the use of these conventional antidepressants increases IELT two- to nine-fold above baseline, compared to three- to eight-fold when dapoxetine is used. [11] However, these SSRIs may need to be taken daily to achieve meaningful efficacy, and their comparatively longer half-lives increase the risk of drug accumulation and a corresponding increase of adverse effects such as reduced libido. [13] Dapoxetine, though, is generally categorized as a fast-acting SSRI. It is more rapidly absorbed and mostly eliminated from the body within a few hours. The incidence of antidepressant discontinuation syndrome symptoms in men using dapoxetine to treat PE has been described by reviewers as low or no different from the incidence of such symptoms in men withdrawn from placebo treatment.

The safety of Priligy has been evaluated in multiple studies.
It’s recommended to start at the lowest dose.
Dose adjustments may be necessary based on response.
Use is contraindicated in certain health conditions.
It’s important to disclose all medical history.
Patients should be aware of the potential for side effects.
Priligy is part of a broader therapy approach.
Use caution if combining with other serotonergic drugs.
Always store medications out of children’s reach.

[33][34] The lack of chronic serotonergic stimulation with on-demand dapoxetine minimizes the potentiation action of serotonin at synaptic cleft, thus decreasing the risk of discontinuation symptoms. Currently, very few methods are used to synthesize (S)-dapoxetine.

Dapoxen 30