This reaction releases nitric oxide, relaxing the smooth muscle tissue inside the penis and increasing blood flow that is needed to obtain an erection. Clinical trials found that 65% of men who used MED3000 achieved an erection within 10 minutes and maintained it long enough to have sex.
Uses / Indications
LeWine, MD, Chief Medical Editor, Harvard Health Publishing; Editorial Advisory Board Member, Harvard Health Publishing Men will soon have a new option for treating erectile dysfunction (ED) that supposedly works faster than regular ED medication — and is available without a prescription. In June, the FDA approved the over-the-counter sale of MED3000 (Eroxon), a topical gel treatment for ED. MED3000 is supplied in single-use tubes. The contents are rubbed onto the head of the penis immediately before sexual intercourse. The gel contains a combination of volatile solvents which, when applied to the head of the penis, evaporate rapidly, stimulating nerve endings through an initial cooling effect, followed by a warming sensation. Common prescription ED drugs like tadalafil (Cialis) and sildenafil (Viagra) take around 30 minutes to work.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 25mg | 360 + 10 Pills | 213.68€ 203.50€ | |
| Viagra Generic | 50mg | 180 + 8 Pills | 158.82€ 151.26€ | |
| Viagra Generic | 200mg | 120 + 8 Pills | 204.80€ 195.05€ | |
| Kamagra Soft Tabs | 100mg | 12 Pills | 57.55€ 54.81€ | |
| Kamagra | 100mg | 20 Pills | 86.09€ 81.99€ | |
| Kamagra | 100mg | 12 Pills | 55.64€ 52.99€ | |
| Kamagra | 100mg | 32 Pills | 121.24€ 115.47€ | |
| Viagra Generic | 200mg | 30 + 2 Pills | 83.07€ 79.11€ | |
| Kamagra Oral Jelly | 100mg | 10 Sachets | 54.55€ 51.95€ | |
| Viagra Generic | 200mg | 270 + 10 Pills | 379.76€ 361.68€ | |
| Viagra Generic | 200mg | 10 Pills | 40.96€ 39.01€ | |
| Viagra Generic | 100mg | 60 + 4 Pills | 96.36€ 91.77€ | |
| Kamagra Oral Jelly | 100mg | 30 + 5 Sachets | 136.20€ 129.71€ | |
| Kamagra Soft Tabs | 100mg | 20 Pills | 79.79€ 75.99€ | |
| Kamagra Soft Tabs | 100mg | 84 + 4 Pills | 233.05€ 221.95€ | |
| Kamagra Polo | 100mg | 272 + 12 Pills | 622.94€ 593.28€ | |
| Kamagra Soft Tabs | 100mg | 32 Pills | 120.11€ 114.39€ |
The common side effects of MED3000 were headaches and nausea, but these occurred in only 1% to 3% of men. No side effects were reported among sexual partners.
Diet & Lifestyle Tips
A gel base, without medicament (vehicle only), was applied vaginally in a dose of 5 gm twice per day, from cycle day 8 to the day of HCG administration ( when follicular diameter reached 18 mm). Endometrial thickness and Uterine artery Doppler assessment were done in the late proliferative phase ( Day of HCG injection).~Seventh cycle ( Sildenafil vaginal gel and Clomiphene cycle):~Those who didn't conceive on the sixth cycle (41 women) were asked to have an extra (7th) cycle in which they were prescribed the usual dose of Clomiphene citrate in addition to sildenafil vaginal gel. The dose was 5 g gel containing 50 mg sildenafil, applied vaginally twice daily from cycle day 8 to Day of HCG injection. The gel was prepared in collaboration with the department of pharmaceutics, faculty of Pharmacy, Assiut University. Sixty grams of gel were prepared in tubes and every patient was given 10 applicators like that used for administration of vaginal antimycotic creams to use them for applying the gel.~Evaluation of the study end points:~On day of HCG injection (main follicular diameter of 18 mm) in the 6th, and 7th cycles, women came for follow up and had transvaginal sonographic assessment of their endometrial thickness.
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In addition, Transvaginal Doppler examination was also done on the same visit to evaluate the pulsatility indices of both uterine arteries. When the leading follicle reached 18 mm in diameter, 5000 IU of HCG was prescribed for IM injection.~Although pregnancy rate was not a primary outcome measure in the study, investigators sildenafil citrate sublingual tablets 100mg detected pregnancy in 3 cases in the cohort of 36 cases of infertile women with clomiphene failure in which sildenafil gel was added as an adjuvant. Pregnancy was diagnosed with a B-HCG value above 100 mIU/ml, and confirmed later with ultrasound.~Statistics:~Data were analyzed using SPSS program ver. 17 using Student-t-test and Fisher's exact test for comparing data in the 6th and 7th cycles, as appropriate. Reviewed by Howard E. U.S.
- Application techniques usually recommend applying the gel and gently rubbing it in.
- Some formulations of sildenafil gel may be water-based or alcohol-based.
- Quality control in manufacturing ensures consistent dosing and safety.
- Sildenafil gel may be used as an alternative or adjunct to oral ED medications.
- Research into novel delivery systems is ongoing to improve sildenafil gel efficacy.
- Patients are advised to avoid washing the application area immediately after use.
- Monitoring for allergic reactions is necessary during initial uses.
prices are not yet available, but in the United Kingdom, where Eroxon is already available over-the-counter, the cost is equivalent to about $32 (U.S.) for a four-pack. Matthew Solan, Former Executive Editor, Harvard Men's Health Watch Howard E. LeWine, MD, Chief Medical Editor, Harvard Health Publishing; Editorial sildenafil oral jelly 100 mg Advisory Board Member, Harvard Health Publishing As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles.
| Drug Class | Examples | Effect | Recommendation |
|---|---|---|---|
| Nitroglycerin | Nitroglycerin | Severe hypotension | Avoid concomitant use |
| Alpha-blockers | Doxazosin, Tamsulosin | Enhanced blood pressure lowering | Use with caution |
| CYP3A4 inhibitors | Ketoconazole, Erythromycin | Increased sildenafil plasma levels | Dose adjustment may be necessary |
| Other PDE5 inhibitors | Tadalafil, Vardenafil | Additive effect and increased risk of side effects | Avoid combining |
No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Sildenafil is commonly used for the following conditions. Erectile dysfunction, a condition where you have trouble getting or keeping an erection Pulmonary arterial hypertension, a condition where you have high blood pressure in the blood vessels that carry blood from your heart to your lungs Sildenafil may also be used for other conditions as determined by your healthcare provider. Sildenafil works by blocking an enzyme in the body called PDE5, which helps relax certain blood vessels.
4. Conclusions
Keep it out of reach of children and pets. If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Yes, a prescription is typically required for this medication. Consult your healthcare provider to determine if it is appropriate for you.
3.6. Preparation of Sildenafil-Loaded Bilosomal Gel
This gel is specifically formulated for vaginal use and is not intended for use by men. Consult a healthcare provider for appropriate treatments for male conditions. Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.No compounded medications are reviewed by the FDA for safety or efficacy. For erectile dysfunction, it increases blood flow to the penis when aroused. This makes it easier to get and keep an erection. For pulmonary arterial hypertension, sildenafil relaxes the blood vessels in the lungs. This lowers blood pressure and reduces strain on the heart. 10 mg/mL powder for oral suspension 20 mg, 25 mg, 50 mg, 100 mg oral tablets Sildenafil is also available in an injectable form that is usually given by a healthcare provider in a hospital or clinic. Sildenafil oral tablets should be stored at room temperature, between 68 F to 77 F (20 C to 25 C).
What should I know about storage and disposal of this medication?
No compounded medications are reviewed sildenafil citrate tablets 150 mg by the FDA for safety or efficacy. Calculate the required quantity of each ingredient for the total amount to be prepared. Accurately weigh and/or measure each ingredient. Thoroughly pulverize the required number of sildenafil tablets for the prescription. (A high-speed mill/coffee grinder works well.) Add the propylene glycol and purified water to the sildenafil citrate powder, and form a smooth paste.
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
Incorporate into sufficient hydrophilic ointment (Dermabase, Vanicream) to final weight and mix well. Warm the purified water to about 70°C and add to the powder-propylene glycol mixture. Package in tight, light-resistant containers.1 A beyond-use date of 14 days can be used for this preparation when stored in a refrigerator.1 Sildenafil cream and sildenafil gel have been used to improve uterine artery flow and endometrial development in patients undergoing in vitro fertilization. Study design:~This is a prospective self-controlled clinical trial.~Study subjects:~Investigators counseled and recruited 42 infertile women who had been diagnosed with anovulatory infertility, with normal baseline FSH, LH, and free testosterone levels, patent tubes on hysterosalpingography, and normal male semen analysis.~By the time they were enrolled in the study, all women had already completed 5 ovulatory cycles of Clomiphene citrate induction (in a dose of 100 mg/ day in two divided doses starting from day 3 of the cycle for 5 days) but without conception (clomiphene citrate failure) with thin endometrium (\<8mm) in at least 3 cycles. Ovulation was documented sonographically, and with day-21 serum progesterone exceeding 5 ng/ ml in all cases.~Exclusion criteria:~Women with major medical problems, male factor infertility, endocrine abnormalities such as hyperprolactinemia or abnormal thyroid functions, prior ovarian or adnexal surgery, or organic pelvic pathology were not included in the study.~Intervention:~Sixth cycle (Clomiphene citrate only):~Enrolled cases were asked to continue with Clomiphene citrate induction ( at the same dose) for the 6th cycle. It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it.
Why is this medication prescribed?
This gel is used for delivering medication or providing lubrication and therapeutic effects for various gynecological purposes. It is specifically formulated for easy and controlled application in the vaginal area. The gel should be applied as directed by your healthcare provider. Typically, it is dispensed from a tube and applied directly to the vaginal area for optimal therapeutic effects. You should consult your healthcare provider before using this gel if you are pregnant or breastfeeding to ensure it is safe for you and your baby.
Incidence not known
Some users may experience mild irritation or discomfort. If you experience severe side effects or an allergic reaction, discontinue use and consult your healthcare provider immediately. The frequency of use should be determined by your healthcare provider based on your specific needs and condition. Before using this gel with other vaginal products, consult your healthcare provider to avoid potential interactions or reduced effectiveness. Store the gel at room temperature, away from direct sunlight and moisture. Sildenafil oral liquid should be stored at room temperature below 86 F (30 C) or in the refrigerator, between 36 F to 46 F (2 C to 8 C). Throw away any remaining liquid 60 days after it has been mixed for you by a pharmacist or healthcare professional.
- Sildenafil gel use requires patient education for proper technique.
- Patients should not exceed recommended dose frequency.
- Combining sildenafil gel with other ED treatments should be medically supervised.
- Gel containers are often designed for one-time dosing to avoid contamination.
- The gel consistency affects the ease and speed of application.
- Some topical gels include ingredients to enhance penile sensitivity.
- Avoid applying near the eyes or mucous membranes.
Sildenafil injection is usually given by a healthcare provider in a hospital or clinic. You will not store it at home. The most common side effects of sildenafil are listed below.
| Use Case | Typical Dose | Application Area | Onset of Action | Duration of Effect |
|---|---|---|---|---|
| Erectile Dysfunction | 10 mg | Penis (integumentary) | 15-30 minutes | Up to 4 hours |
| Pulmonary Hypertension | 10-20 mg | N/A (transdermal) | 20 minutes | 3-6 hours |
| Delayed Onset of Erection | 10 mg | Penile tissue | 10-20 minutes | 2-4 hours |
These side effects may vary depending on the condition that is being treated.
- Instruction for use often recommends a waiting period after application before intercourse.
- The gel's bioavailability varies with formulation and skin condition.
- Patient satisfaction surveys show positive response to topical sildenafil.
- Sildenafil gel can be compounded by pharmacies for personalized dosing.
- Avoid contact of gel with female partners’ genital mucosa to prevent irritation.
- Gel may be combined with lubricants if compatible.
- Market availability depends on regulatory approvals in different countries.
Tell your healthcare provider if you have any of these side effects that bother you.
| Ingredient | Concentration | Purity (%) | Solvent Used | pH Level | Preservatives |
|---|---|---|---|---|---|
| Sildenafil Citrate | 10 mg/g | 99.5 | Propylene Glycol | 5.5 | Methylparaben |
| Glycerin | -- | -- | -- | -- | -- |
| Carbomer | 1.5% | -- | -- | -- | -- |
| Ethanol | 2% | -- | -- | -- | -- |
| Purified Water | q.s. to 100g | -- | -- | -- | -- |
Pain in your muscles, back, arms, or legs There may be other side effects of sildenafil that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine.