All patients were instructed to record their intravaginal ejaculatory latency time (IELT). They were also instructed to complete Premature Ejaculation Diagnostic The study was completed with 53 patients (71.62%).
- Some users report improved stamina and control during intercourse.
- Enhanced satisfaction for both partners is a common benefit.
- Reduced anxiety about performance can boost mental well-being.
- Relationship intimacy often improves with successful treatment.
- Avoid unrealistic expectations; results vary per individual.
- Patience is key as full benefits may take several uses.
- Track progress with a journal to discuss with your doctor.
- Combine with foreplay and communication for best experience.
- Celebrate small victories to maintain positive outlook on therapy.
Mean age of the patients was 45.32±10.05. Before the treatment, geometric mean IELT of the patients was 22.72±15.16 seconds, mean PEDT score was 16.85±2.42, mean PEP score was 3.36±1.12and IIEF-EF score was 13.17±3.33.
| Tip | Explanation | Ideal Conditions | Duration |
|---|---|---|---|
| Keep in a cool, dry place | Avoid humidity and heat | Store at room temperature (<25°C) | Up to 2 years |
| Keep away from direct sunlight | Prevent degradation of active ingredients | In a dark, airtight container | Up to 2 years |
| Keep out of reach of children | To prevent accidental ingestion | In locked cabinet | Indefinitely |
| Check expiry date | Ensure medication potency before use | Before consumption | As indicated on packaging |
At the end of the 4-week treatment period, statistically significant improvements were observed in the mean IELTs, PEP and IIEF-EF scores compared to the patients' pre-treatment values (69.47±103.34;p<0.001, 9.92±2.36;p<0.001, The dapoxetine/ sildenafil combination therapy significantly improves the IELT values and patient reported outcome measures of PE patients who also suffer from ED. Although several side effects were reported, these were mild and reversible. Premature ejaculation (PE) is a major issue in male sexual health.
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Conservative Non-surgical Options for Erectile Dysfunction Current Urology Reports (2023) The role of tyrosine hydroxylase within dapoxetine-assisted therapy against premature ejaculation Molecular Biology Reports (2023) Current and emerging treatment options for premature ejaculation Nature Reviews Urology (2022) Redefining a sexual medicine paradigm: subclinical premature ejaculation as a new taxonomic entity Nature Reviews Urology (2021) 058 The Efficacy and Safety of Dapoxetine / Sildenafil Combination Therapy in the Treatment of Men with Premature Ejaculation and Erectile Dysfunction – DAP-SPEED Study - ScienceDirect Please enable JavaScript to use all the features on this page. 058 The Efficacy and Safety of Dapoxetine / Sildenafil Combination Therapy in the Treatment of Men with Premature Ejaculation and Erectile Dysfunction – DAP-SPEED Study Author links open overlay panelM.Tuken1, M.G.Culha2, E.C.Serefoglu3 Premature ejaculation (PE) and erectile dysfunction (ED) are the most prevalent sexual disorders in men. ED is commonly reported among patients with PE.Although recent guidelines recommend to treat ED first in men with both PE and ED, this recommendation is not based on evidence and there is limited data about the efficacy and safety of dapoxetin / sildenafil combination therapy for these patients. The aim of this study is to evaluate the clinical efficacy and safety of the dapoxetine / sildenafil combination (Dapoxil 30/50 mg film-coated tablet) in the treatment of patients with PE and concomitant ED. In a single-center, single-arm, open-label clinical study, 74 patients with lifelong / acquired PE and ED were included between October 2016 to September 2017.Patients received on demand dapoxetine / sildenafil (30/50 mg film-coated tablets) 1-3 hours before sexual intercourse for 4 weeks (2 days a week and no more than once a day). The global prevalence of PE is estimated to be between 20% and 40%, making it the most common sexual dysfunction in men.
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PE causes distress and reduced quality of life for patients and has a negative impact on interpersonal relationships.
How does it feel in real use?
Men C, Yu L, Yuan H, Cui Y. Efficacy and safety of phosphodiesterase type 5 inhibitors on primary premature ejaculation in men receiving selective serotonin reuptake inhibitors therapy: a systematic review and meta-analysis. Asimakopoulos AD, Miano R, Finazzi Agro E, Vespasiani G, Spera E. Does current scientific and clinical evidence support the use of phosphodiesterase type 5 inhibitors for the treatment of premature ejaculation? Efficacy of type-5 phosphodiesterase inhibitors in the drug treatment of premature ejaculation: a systematic review.
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Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors. Turkish validation of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time. The comparison of premature ejaculation assessment questionnaires and their sensitivity for the four premature ejaculation syndromes: results from the Turkish society of andrology sexual health survey. Patrick DL, Giuliano F, Ho KF, Gagnon DD, McNulty P, Rothman M. The Premature Ejaculation Profile: validation of self-reported outcome measures for research and practice.
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Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. An empirical buy soft viagra operationalization study of DSM-IV diagnostic criteria for premature ejaculation. A tutorial on pilot studies: the what, why and how. Advances in understanding and treating premature ejaculation. Historically, it has been treated with cognitive therapy, behavioral methods, and off-label use of selective serotonin reuptake inhibitors usually used to treat depression and other psychological disorders.
- Viagra with Dapoxetine can be taken with food but delays absorption.
- Fatty meals may reduce effectiveness; opt for light snacks instead.
- Grapefruit juice increases side effect risks; avoid entirely.
- Caffeine may amplify dizziness or jitteriness in some users.
- Stay hydrated but avoid excessive fluid intake before sex.
- Alcohol can impair judgment and increase side effect severity.
- Combining with other stimulants is not advised for safety.
- Follow a consistent routine to achieve optimal drug performance.
- Keep a log of meals and drug timing to track effects.
Dapoxetine is a selective serotonin reuptake inhibitor specifically designed to treat PE.
Sources & References Sildenafil – MedlinePlus (NIH) https://medlineplus.gov/druginfo/meds/a699015.html Sildenafil increases blood flow to the penis during sexual stimulation to treat erectile dysfunction. (MedlinePlus)Sildenafil – NCBI (NIH StatPearls) https://www.ncbi.nlm.nih.gov/books/NBK558978/ Sildenafil is a PDE5 inhibitor used for erectile dysfunction and works by relaxing vascular smooth muscle to improve blood flow. (NCBI)VIAGRA (Sildenafil) – FDA Label https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/20895s039s042lbl.pdf FDA-approved sildenafil is indicated for erectile dysfunction and acts via cyclic GMP pathway inhibition. (FDA Access Data)Dapoxetine for Premature Ejaculation – NIH (PMC) https://pmc.ncbi.nlm.nih.gov/articles/PMC3888071/ Dapoxetine is an effective and safe treatment for premature ejaculation and represents a major advance in sexual medicine. (PMC)Serotonin Syndrome – MedlinePlus (NIH) https://medlineplus.gov/ency/article/007272.htm Excess serotonin from medications like SSRIs can cause serotonin syndrome, highlighting safety concerns with drugs like dapoxetine. (MedlinePlus) Prescription Required (Rx) to Buy? This medication is not available over the counter. A valid prescription from a licensed healthcare professional is required. Always consult your doctor before use.
An evidence-based unified definition of lifelong and acquired premature ejaculation: report of the Second International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation. Patrick DL, Althof SE, Pryor JL, Rosen R, Rowland DL, Ho KF, et al. Premature ejaculation: an observational study of men and their partners. An update of the International Society of Sexual Medicine’s Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE). Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials.
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Efficacy of dapoxetine for the treatment of premature ejaculation: a meta-analysis of randomized clinical trials on intravaginal ejaculatory latency time, patient-reported outcomes, and adverse events. Park HJ, Park NC, Kim TN, Baek SR, Lee KM, Choe S. Discontinuation of dapoxetine treatment in patients with premature ejaculation: a 2-year prospective observational study. Mondaini N, Fusco F, Cai T, Benemei S, Mirone V, Bartoletti R. Dapoxetine treatment in patients with lifelong premature ejaculation: the reasons of a “Waterloo”.
Satisfaction with sexual intercourse
Premature ejaculation and erectile dysfunction prevalence and attitudes in the Asia-Pacific region. AUA guideline on the pharmacologic management of premature ejaculation. EAU guidelines on erectile dysfunction, premature ejaculation, penile curvature and priapism. Arnhem, The Netherlands: EAU Guidelines Office; 2018. Efficacy of phosphodiesterase-5 inhibitor in men with premature ejaculation: a new systematic review and meta-analysis. This paper reviews the current evidence for use of dapoxetine in the treatment of PE in adult men.
| Benefit | Description | Common Platforms | Additional Notes |
|---|---|---|---|
| Convenience | Purchase from home without doctor's visit | Online pharmacies | Discreet packaging |
| Cost-effectiveness | Lower prices compared to local pharmacies | Licensed online stores | Check for authenticity |
| Privacy | Confidential transaction | International sellers | Reduces social stigma |
| Discreet Delivery | Products shipped in plain packaging | Various online vendors | Ensures privacy |
| Accessibility | Available 24/7 without location constraints | E-pharmacies | Can bypass local restrictions |
There is substantial evidence that dapoxetine 30 mg or 60 mg taken “on-demand” results in a significant increase in intravaginal ejaculatory latency time when compared with placebo. Patient-reported outcomes are clearly improved relative to placebo following dapoxetine therapy, indicating greater control over ejaculation, more satisfaction with intercourse, less ejaculation-related distress, and, importantly, significantly reduced interpersonal difficulty.
| Ingredient | Purpose | Concentration | Brand Names |
|---|---|---|---|
| Sildenafil citrate | Erectile dysfunction relief | 50mg, 100mg | Viagra, Caverta |
| Dapoxetine | Premature ejaculation control | 30mg, 60mg | Priligy, Dapoxetine |
| Microcrystalline cellulose | Tablet filler | N/A | Various brands |
| Magnesium stearate | Lubricant in manufacturing | N/A | Various brands |
| Hypromellose | Coating agent | N/A | Various brands |
These data were supported by consistent reports of improvement in Clinical Global Impression of change in PE following treatment with dapoxetine.
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Acceptance of and discontinuation rate from paroxetine treatment in patients with lifelong premature ejaculation. McMahon CG, Porst H. Oral agents for the treatment of premature ejaculation: review of efficacy and safety in the context of the recent International Society for Sexual Medicine criteria for lifelong premature ejaculation. A prospective study comparing paroxetine alone versus paroxetine plus sildenafil in patients with premature ejaculation. Mattos RM, Marmo Lucon A, Srougi M.
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Tadalafil and fluoxetine in premature ejaculation: prospective, randomized, double-blind, placebo-controlled study. Comparison between on-demand dosing of dapoxetine alone and dapoxetine plus mirodenafil in patients with lifelong premature ejaculation: prospective, randomized, double-blind, placebo-controlled, multicenter study. Corona G, Rastrelli G, Limoncin E, Sforza A, Jannini EA, Maggi M. Interplay between premature ejaculation and erectile dysfunction: a systematic review and meta-analysis. Uckert S, Oelke M, Stief CG, Andersson KE, Jonas U, Hedlund P.
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Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate. Functional responses of isolated human seminal vesicle tissue to selective phosphodiesterase inhibitors. Efficacy and safety of dapoxetine in men with premature ejaculation and concomitant erectile dysfunction treated with a phosphodiesterase type 5 inhibitor: randomized, placebo-controlled, phase III study. Comparative effectiveness and safety of oral phosphodiesterase type 5 inhibitors for erectile dysfunction: a systematic review and network meta-analysis. The authors would like to thank Neutec Ar-Ge San & Tic AS Clinical Research Department for their cooperation. Further studies are needed to evaluate long-term efficacy and health economics. The unique pharmacology of dapoxetine makes it ideal for on-demand dosing, and the clinical evidence shows dapoxetine to be an efficacious and tolerable treatment for lifelong and acquired PE.
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This study has been sponsored by Neutec Ar-Ge San & Tic AS (Turkey). The authors declare that they have no conflict of interest. Publisher’s note: Springer Nature remains neutral viagra connect form with regard to jurisdictional claims in published maps and institutional affiliations. Efficacy and safety of dapoxetine/sildenafil combination tablets in the treatment of men with premature ejaculation and concomitant erectile dysfunction—DAP-SPEED Study. What Is the Role of Ejaculation Latency in the Diagnosis of Premature Ejaculation and Does the Ejaculation Latency Threshold Matter? Keywords: dapoxetine, intravaginal ejaculatory latency time, patient-reported outcomes, premature ejaculation Dapoxetine (PriligyTM, Johnson and Johnson, Raritan, NJ) is the first and only product licensed for the treatment of premature ejaculation (PE) in men aged 18–64 years.